- Dwayne Johnson as Luke Hobbs
- Jason Statham as Deckard Shaw
- Idris Elba as Brixton Lore
- Vanessa Kirby as Hattie Shaw
- Cliff Curtis as Jonah Hobbs
- Helen Mirren as Magdalene Shaw
- Eiza González as Madam M
A crew of MI6 agents, led by Hattie Shaw, enter a warehouse run by the techno-terrorist organization Etheon and attempt to retrieve a virus, Snowflake, that can be programmed to kill people. Luke Hobbs and Deckard Shaw are both informed of the missing Snowflake and are assigned to work together to track it down. They have no choice but work together to resolve the situation although they both are irritated to work together.